Search results for "Sciatic nerve injury"

showing 3 items of 3 documents

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

2016

Peripheral or central nerve injury is a frequent cause of chronic pain and the mechanisms are not fully understood. Using newly generated transgenic mice we show that progranulin overexpression in sensory neurons attenuates neuropathic pain after sciatic nerve injury and accelerates nerve healing. A yeast-2-hybrid screen revealed putative interactions of progranulin with autophagy-related proteins, ATG12 and ATG4b. This was supported by colocalization and proteomic studies showing regulations of ATG13 and ATG4b and other members of the autophagy network, lysosomal proteins and proteins involved in endocytosis. The association of progranulin with the autophagic pathway was functionally confi…

0301 basic medicineAutophagy-Related ProteinsMiceProgranulinsGanglia SpinalDorsal root gangliaGranulinsPain MeasurementCD11b AntigenMicrofilament ProteinsChronic painSciatic nerve injuryCysteine Endopeptidasesmedicine.anatomical_structureNociceptionNeurologyNeuropathic painIntercellular Signaling Peptides and Proteinsmedicine.symptomMicrotubule-Associated ProteinsNerve injuryProgranulinSensory Receptor CellsGreen Fluorescent ProteinsPainMice Transgeniclcsh:RC321-571ATG1203 medical and health sciencesLysosomal-Associated Membrane Protein 1mental disordersmedicineAutophagyAnimalslcsh:Neurosciences. Biological psychiatry. NeuropsychiatryActivating Transcription Factor 3Sensory neuronbusiness.industryAutophagyCalcium-Binding ProteinsNerve injurymedicine.diseaseSensory neuronMice Inbred C57BLDisease Models Animal030104 developmental biologyGene OntologyNeuralgiabusinessApoptosis Regulatory ProteinsNeuroscienceNeurobiology of Disease
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Neuroprotective potential of erythropoietin and darbepoetin alfa in an experimental model of sciatic nerve injury. Laboratory investigation.

2007

Object The objectives of this study were to examine whether the systemic administration of recombinant human erythropoietin (rHuEPO) and its long-lasting derivative darbepoetin alfa expedited functional recovery in a rat model of sciatic nerve injury, and to compare the effects of these agents in the model. Methods Thirty male Sprague–Dawley rats received a crush injury to the left sciatic nerve and subsequently underwent either placebo treatment, daily injections of rHuEPO, or weekly injections of darbepoetin alfa. Results Both rHuEPO and darbepoetin alfa were effective in reducing neurological impairment and improving compound muscle action potentials following nerve injury. Darbepoetin …

MaleTime FactorsDarbepoetin alfaNerve CrushAction PotentialsPlaceboDrug Administration ScheduleRats Sprague-Dawleyadministration /&/ dosage/pharmacologymedicineAnimalsHumansDarbepoetin alfaMuscle SkeletalErythropoietinERYTHROPOIETINdrug effects/injuries/physiopathologySettore MED/27 - Neurochirurgiabusiness.industryAction Potentials; drug effects Animals Drug Administration Schedule Erythropoietin; administration /&/ dosage/analogs /&/ derivatives/pharmacology Humans Male Muscle; Skeletal; physiopathology Nerve Crush Neuroprotective Agents; administration /&/ dosage/pharmacology Rats Rats; Sprague-Dawley Recombinant Proteins Recovery of Function; drug effects Sciatic Nerve; drug effects/injuries/physiopathology Time FactorsGeneral MedicineSkeletalRecovery of FunctionNerve injurySciatic nerve injurymedicine.diseaseadministration /&/ dosage/analogs /&/ derivatives/pharmacologySciatic NerveNeuroprotectionRecombinant ProteinsRatsNeuroprotective AgentsNeurologyErythropoietinPeripheral nerve injuryAnesthesiadrug effectsPeripheral nerve injuryCrush injuryMuscleSurgeryNeurology (clinical)Sciatic nerveSprague-Dawleymedicine.symptomphysiopathologybusinessmedicine.drug
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Does granulocyte-colony stimulating factor stimulate peripheral nerve regeneration? An experimental study on traumatic lesion of the sciatic nerve in…

2021

Aim of the study. To analyse the therapeutic potential of granulocyte-colony stimulating factor (G-CSF) treatment using a rat model of traumatic sciatic nerve lesion. Clinical rationale for the study. G-CSF has proven strong neurotrophic properties in various models of ischaemic and traumatic brain injury. Fewer studies exist regarding the influence of G-CSF on posttraumatic peripheral nerve regeneration. Currently, the possibilities of pharmacological prevention or treatment of mechanical nerve injury are limited, and there is an urgent need to find new treatment strategies applicable in clinical situations. Material and methods . A controlled traumatic right sciatic nerve lesion was set u…

Traumatic brain injuryLesionGranulocyte Colony-Stimulating FactormedicineAnimalsHumansbiologybusiness.industrySciatic nerve injuryNerve injurymedicine.diseaseSpinal cordSciatic NerveGranulocyte colony-stimulating factorNerve RegenerationRatsDisease Models Animalmedicine.anatomical_structureAnesthesiabiology.proteinSurgeryNeurology (clinical)Sciatic nervemedicine.symptomSciatic NeuropathybusinessNeurotrophinGranulocytesNeurologia i neurochirurgia polska
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